2 large boneless, skinless chicken breasts, cut into even bite-sized pieces
1 box yellow or white cake mix
2 large eggs, beaten
2 cups panko breadcrumbs
1/2 teaspoon garlic powder
1/4 to 1/2 teaspoon cayenne pepper
1 teaspoon kosher salt
1/4 teaspoon fresh ground black pepper
Preheat the oven to 425°F. Prepare a baking sheet with parchment paper and set aside.
Prepare the ingredients for breading in three separate wide, shallow bowls, and arrange in an assembly line. Place 1 cup of the cake mix in the first bowl; the eggs in the second bowl; and the panko, garlic powder, cayenne, salt, and pepper in the third bowl.
Bread the chicken pieces one at a time. Dredge in the cake mix, tossing to fully coat each piece and then shaking off any excess; dip in the beaten eggs; and finally toss in the panko mixture, fully coating each piece. Transfer the chicken to the prepared baking sheet, then repeat with the remainder of the pieces.
Bake until the chicken nuggets are golden-brown and cooked through, 10 to 12 minutes, flipping once halfway through. Remove from the oven and serve immediately.